Endocrine Abstracts

INTRODUCTIONWe assessed the long-term outcomes of patients managed with intermittent androgen suppression (IAS) following their enrolment in an open, non-randomised feasibility study initiated 10 years ago.PATIENTS AND METHODSAll patients were required to have been managed with androgen suppression for a minimum of 9 months and achieved PSA remissions to levels <4ng/ml. Therapy was stopped and the patients...

Pro-opiomelanocortin (POMC) derived peptides coordinate energy balance via central melanocortin receptors. In order to monitor central POMC expression and processing in-vivo, we have quantified the POMC derived peptides ACTH, alpha-MSH and the high molecular weight precursors POMC/proACTH in rat cerebrospinal fluid (csf). POMC/proACTH levels were significantly lower in csf samples from fasted versus fed rats (65.2 ± 4.5 pmol/l versus 112 ± 10.1 pmol/l; p = 0.00...